Electromagnetic Radiation can Eliminate Resistance to Medications in Severely Depressed (Kunaal Gupta)

Indian researchers have been very promising results of experiments with the hat that through seven magnets sends electromagnetic pulses across the patient's skull. The Rays resets the receptors that were previously blocked, so the medicine is working again.

With magnetic hat represent a future treatment which shall take a half hour a day and can be done in the comfort of home on the couch.

Risk of, chronic depression

"About 30% of patients suffering from severe depression are resistant to medical treatment. And it can actually give them a chronic depression," according to experts. The problem is that the brain's receptors become oversaturated of medicine. This means that one can not treat. But the problem solver magnetic hat with electromagnetism. When power is applied to the seven magnets occurs electromagnetic pulse, which was down to the cellular level affect brain receptors.

Patients with depression who were treated with the helmet, it got significantly better. Their depression fell 20 steps of the so-called Hamilton-scale. It is the scale that is used to specify a numerical value for how severe a patient's depression. For the control group, who received the helmet on, but was not aware that there was no power to the magnets, decreased the degree of depression five steps.

Inspired by electroshock

In the 1990s, experiments with electric shocks, patients with severe psychosis that way again became susceptible to their medication. The patient had general anesthesia during the electro-shock, and the positive effect only lasted for about two months.

"The patients were all a kind of dry helmet on his head. The helmet seven coils create an electromagnetic field of the skull when you put power to the helmet. The magnetic field will go in and affect the impulses in the brain's nerve center," explains Per Bech.

The new magnethats treatment called PEMF (pulsed electromagnetic fields) which in a sense is a further development of Transcranial Magnetic Stimulation (TMS). Unlike TMS, which can cause some side effects, such as headaches, have PEMF therapy in the first study not given them. And that's some of the things you in Hillingdon will test in some dose-response studies to begin in the autumn.

Back to life

Magnetic hat is developed in collaboration with Professor Steen Dissing from the Department of Cellular and Molecular Medicine at the Panum Institute, University of Copenhagen. He is working to make the hat more comfortable to wear, so patients in the future may have a helmet at home.

"If you get sick today, and ends with resistance to medication or therapy, it is an admission the next step. It's hard for yourself and your family, like a prolonged hospitalization also costly to society, for example if you lose your work in progress, " says experts.

In view of the good results, the researchers will now investigate whether magnetic hat can completely eliminate the need for medication. The next step is after the analysis of the trial, various approvals and additional testing, so some years before the expected magnetic hat to become widely available.

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Amitriptyline belongs to class of medications called tricyclic antidepressants (Lily Wilson Rose)

Elavil (Amitriptyline) is FDA-marked in adults and in teenagers and kids over 12 years of age for depression. It is utilized basically to treat significant wretchedness (both maniacal and endogenous), particularly discouragement connected with a slumber aggravation. On account of its soothing impacts, it might be valuable in treating tension connected with sorrow. Elavil ought not to be utilized for bipolar issue (manic discouragement) as it may accelerate a manic scene.

Elavil might likewise be recommended to treat:

nerve torment (neurogenic ache)chronic, extreme agony and torment disorders, for example, ciguatera, posttherpetic neuralgia, neuropathic, and vulvodynia.agitationanorexiabulimia connected with discouragementinsomniaIt is additionally helpful in treatment for nerve torment, ceaseless agony disorders, headaches/headache avoidance, nighttime enuresis and a sleeping disorder.

The amount of this medication is ordinarily utilized?
Tablet: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg

In Adolescents:

Initial: 25-50 mg/day; may give in isolated measurements; expand step by step to 100 mg/day in partitioned dosages; most extreme dosage: 200 mg/dayIn Children: Investigationally: introductory measurements of 1 mg/kg/day given in 3 separated dosages with expansions to 1.5 mg/kg/day have been accounted for in a little number of kids (n=9) 9-12 years old Clinically, measurements up to 3 mg/kg/day (5 mg/kg/day if observed nearly) have been propose.

Warnings and Precautions:

Uncommon consideration ought to be utilized within youngsters under twelve years. Elavil should not be utilized within kids under twelve with the exception of under the direction of a youngster therapist.Teenagers (12-18 years of age) have a stronger response to Elavil than do grown-ups and may require littler measurements.Elavil is not addictive. On the other hand, all of a sudden suspending Elavil may cause withdrawal side effects. Doses ought to be step by step decreased to minimize withdrawal. Indeed steady measurement lessening may deliver some withdrawal indications.Elavil can result in photosensitivity and can lessen sweating which impedes the body's capability to adjust to high temperature. Patients ought to evade saunas and other extremely hot situations.Elavil can result in laziness and unsteadiness: a patient taking Elavil ought not drive or work substantial apparatus until he realizes that it doesn't debilitate his capability do participate in these exercises.For Pregnant or Nursing Mothers: Controlled studies have not been carried out in pregnant ladies, however there have been reports of babies experiencing muscle fits and heart, breathing, and urinary issues when their moms had taken tricyclic antidepressants quickly before conveyance. Creature studies demonstrate that some tricyclic antidepressants may have undesirable consequences for an embryo. Tricyclic antidepressants pass into breast milk and are accounted for to cause laziness in nursing babies.

Precautions:

Individuals with a history or danger of seizures may be more helpless against assaults while on TCAs.Different conditions that stance uncommon dangers incorporate glaucoma, coronary illness, sporadic heart rhythms, hyperthyroidism, kidney or liver sickness, and pee issues.Amitriptyline and numerous different Tcas are very steadying. This implies they can make driving or different errands unsafe.More established individuals may be particularly vulnerable to muddlings, for example, sleepiness, tipsiness and perplexity.Hi everyone, this is Lily Rose from USA. I am completed P.HD in pharmacy. I do lots of work in pharmacy and now I am working in rxplusrx.com. I also write blog on all health related product like Mifegest Kit, Order Dilantin online, Penegra, Buy Elavil antidepressants Online, Pristiq, etc.

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Deal with High Depression Effectively with Antidepressant Medications

In today's hectic lifestyle, depression has become very common. According to recent study, it is evaluated that the depression affects millions of people all over the world. It is a mental disease, characterized by sadness, lack of confidence, loss of interest, sleeping disorders, feelings of tiredness, lack of concentration, eating disorders and low self-worth.

It is integral to treat it before it become complicated and incurable. Survey shows that some of the most complicated cases of depression result to suicide and is responsible for about eight lakh death every year in the world.

Most of the time medical care is needed to treat and prevent it from becoming severe. Antidepressants are a group of prescribe drugs used to treat depression and inhibit it from recurring. Some time these medications can also be prescribe to treat several other health problems like OCD(obsessive -compulsive disorder), PTS(Post-traumatic stress disease) and GAD(Generalized anxiety disorder). Most of the time the tablets can also be used to treat chronic body pain.

Today there are numerous types of antidepressants available in the market that can be used to treat depression and conditions that have depression as a component of this disorder, for example a bipolar disorder.

The tablets assist in improving strong sign of the disease by increasing the production of brain chemical, "neurotransmitters". Medical professional believe that this substance can help patients in reducing their level of depression and make their life better.

Some prescribed antidepressants medicines are:

Escitalopram: Escitalopram also known as Lexapro or Cipralex is a prescribe anti-depression medication used to treat major depression disorder. The medicine is approved by FDA and doctor recommendation is essential before taking it. The medicine is not recommended for the children below twelve years. It works directly on the chemicals that are presented in the brain and may become unbalanced and result in uncommon stress and mental disorders.

Tricyclic antidepressants (TCAs): It is one of the most typical medicine used to treat anxiety and stress. The medication work by affecting two brain substances norepinephrine and serotonin. This medicine is prescribe very rarely to the patient because it can cause various side-effects.

Venlafaxine Hydrochloride XR 37.5mg capsules: Venlafaxine is one another prescribe depression medication of the group Serotonin-norepinephrine reuptake inhibitors. This tablet is used to treat high depression.

Duloxetine Hcl 20mg capsule: Duloxetine is one other antidepressants drug of the group erotonin-norepinephrine reuptake inhibitors. This medication can also be used for osteoarthiritis and musculoskeletal pain as it is approved by FDA.

There are many more antidepressants available in the market that patient can consume with suggestion of doctor. People who are suffering from major depression can buy anti-depression drugs online.

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Deal with High Depression Effectively with Antidepressant Medications

In today's hectic lifestyle, depression has become very common. According to recent study, it is evaluated that the depression affects millions of people all over the world. It is a mental disease, characterized by sadness, lack of confidence, loss of interest, sleeping disorders, feelings of tiredness, lack of concentration, eating disorders and low self-worth.

It is integral to treat it before it become complicated and incurable. Survey shows that some of the most complicated cases of depression result to suicide and is responsible for about eight lakh death every year in the world.

Most of the time medical care is needed to treat and prevent it from becoming severe. Antidepressants are a group of prescribe drugs used to treat depression and inhibit it from recurring. Some time these medications can also be prescribe to treat several other health problems like OCD(obsessive -compulsive disorder), PTS(Post-traumatic stress disease) and GAD(Generalized anxiety disorder). Most of the time the tablets can also be used to treat chronic body pain.

Today there are numerous types of antidepressants available in the market that can be used to treat depression and conditions that have depression as a component of this disorder, for example a bipolar disorder.

The tablets assist in improving strong sign of the disease by increasing the production of brain chemical, "neurotransmitters". Medical professional believe that this substance can help patients in reducing their level of depression and make their life better.

Some prescribed antidepressants medicines are:

Escitalopram: Escitalopram also known as Lexapro or Cipralex is a prescribe anti-depression medication used to treat major depression disorder. The medicine is approved by FDA and doctor recommendation is essential before taking it. The medicine is not recommended for the children below twelve years. It works directly on the chemicals that are presented in the brain and may become unbalanced and result in uncommon stress and mental disorders.

Tricyclic antidepressants (TCAs): It is one of the most typical medicine used to treat anxiety and stress. The medication work by affecting two brain substances norepinephrine and serotonin. This medicine is prescribe very rarely to the patient because it can cause various side-effects.

Venlafaxine Hydrochloride XR 37.5mg capsules: Venlafaxine is one another prescribe depression medication of the group Serotonin-norepinephrine reuptake inhibitors. This tablet is used to treat high depression.

Duloxetine Hcl 20mg capsule: Duloxetine is one other antidepressants drug of the group erotonin-norepinephrine reuptake inhibitors. This medication can also be used for osteoarthiritis and musculoskeletal pain as it is approved by FDA.

There are many more antidepressants available in the market that patient can consume with suggestion of doctor. People who are suffering from major depression can buy anti-depression drugs online.

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Deal with High Depression Effectively with Antidepressant Medications

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How tricyclic antidepressants work

If you haven't read a preface, I'd strongly recommend you to look through it: Part 1, 2, 3.

THE TRICYCLIC ANTIDEPRESSANTS

What are the tricyclics used for ?
Tricyclic antidepressants are used to improve mood in people who are feeling low or depressed. The tricyclics may also be used to help the symptoms of anxiety and a number of other symptoms. The tricyclics are the most commonly prescribed antidepressants but there are many other antidepressants. All these drugs seem to be equally effective at the proper dose but have different side effects to each other. If one drug does not suit you, it may be possible to try another.

How do the tricyclics work ?
The brains has many naturally occurring chemical messengers. Two of these are called serotonin (sometimes called 5-HT) and noradrenaline. Both are important in the areas of the brain that control or regulate mood and thinking. It is known that these two chemical messengers are not as effective or active as normal in the brain when someone is depressed. Tricyclic antidepressants increase the amount of these chemical messengers in the brain. This can help correct the lack of action of these messengers and help to improve mood. The tricyclics can also effect another chemical in the brain called "acetylcholine" and this is the cause of some of their side-effects.

"Reduced" nerve activity but with recycling blocked, and increased messages passes:

Side-effects:
Some antidepressants e.g. the tricyclics and venlafaxine, block the reuptake of serotonin and noradrenaline.
Unfortunately, these antidepressant drugs also affect other transmitter systems e.g. acetylcholine, dopamine, histamine etc. Some are a bit like "blunderbuss" treatments i.e. they hit the part that seems to be wrong, but also hit lots of other parts which aren't wrong. The side effects you get from drugs are from these extra "hits". The amount that these drugs effect different transmitters varies between drugs and is the reason you get slightly different side effects from each of the different drugs. These can include:

- If you block acetylcholine receptors, it may blunt your reactions, can produce mild sedation and confusion etc. as well as producing a dry mouth, blurred vision etc.
- Affecting your noradrenaline may also sometimes upset your blood pressure e.g. you may feel dizzy when you stand up etc.
- Too much serotonin and you may feel sick, less hungry, get headaches or migraines
If you block histamine receptors, it can make you feel drowsy (just the same as if you take an antihistamine tablet such as "Piriton" for hay fever or allergy).

Source

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How SSRI antidepressants work

We continue listing different types of antidepressants. If you missed the preface, I'd strongly recommend you to read it here: PART 1, 2, 3

SPECIFIC SEROTONIN RE-UPTAKE INHIBITORS

"What are the SSRI's used for ?

SSRIs are antidepressants which are used to help to improve mood in people who are feeling low or depressed. Fluoxetine ("Prozac") may also be used to help treat the eating disorder "Bulimia nervosa". In addition to this, the SSRIs are now widely used to help a variety of other symptoms. These include anxiety (where a lower starting dose often helps), social phobia and social anxiety, obsessive-compulsive disorder, post-traumatic stress disorder, panic, pre-menstrual syndrome and agoraphobia. Some drugs are "licensed" (ie officially approved) for some of these conditions (e.g. paroxetine for social phobia) but this does not necessarily mean the others do not help, just one manufacturer can prove it and has applied for a licence.
Trazodone ("Molipaxin") and nefazodone ("Dutonin") are not strictly pure "SSRIs" but have many of the same effects and so are included in this group for convenience.
The SSRIs are now one of the most commonly prescribed antidepressants but there are many other similar drugs. All these antidepressants seem to be equally effective at the proper dose but have different side effects to each other. Apart from nausea, the SSRIs generally have less side effects than the older drugs. If one drug does not suit you, it may be possible to try another. Starting with a lower dose for a week or so may also help the drugs to be more tolerable or have less side effects.

How do the SSRI's work ?
The brains has many naturally occurring chemical messengers. One of these are called serotonin (sometimes called 5-HT) and is important in the areas of the brain that control mood and thinking. It is known that this serotonin is not as effective or active as normal in the brain when someone is feeling depressed. The SSRI antidepressants increase the amount of this serotonin chemical messenger in the brain. This can help correct the lack of action of serotonin and help to improve mood."

"Reduced" nerve activity but with recycling blocked, and increased messages passes:

Side-effects:
SSRI antidepressants mainly block the reuptake of just serotonin. This why they are called the SSRIs ie. Selective Serotonin Reuptake Inhibitors.
Many other antidepressant drugs also affect other transmitter systems e.g. acetylcholine, dopamine, histamine etc. and have many side effects. SSRIs really only block the reuptake of serotonin, and so have less side effects. However, they still have some side effects ;-
- Too much serotonin in some parts of the brain can make you feel sick, less hungry and get headaches or migraines.

Source

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How MAOI Antidepressants work

Now let us look carefully at different types of antidepressants. But before doing this, I'd strongly recommens you to read the preface (Parts 1, 2, 3) before you continue to specific types of medicines.

Mono-Amine Oxidase Inhibitors

As we understood from the preface,

"There are many chemical messengers (or "neurotransmitters") called "monoamines" which occur naturally in the body. One of the effects that monoamines have is on mood. If the levels of monoamines in the body are high we may feel 'high', and if they are low we may feel 'low'. MAOIs stop the breakdown of these monoamines. They block the monoamine oxidase enzyme which breaks down the transmitter, so the next time an impulse comes along, there is more transmitter, a stronger message is passed, and activity in that part of the brain is increased. By stopping the breakdown of these, the MAOIs may bring back the amounts of monoamines to normal. This helps to improve mood in people who are feeling low or depressed."

"Reduced" nerve activity but with (mono-amine oxidase) enzyme blocked (or inhibited), and increased messages passed:

Side-effects:
Some antidepressants e.g. the tricyclics, block the reuptake of serotonin and noradrenaline. Others mainly block the reuptake of just serotonin e.g. the SSRIs. The MAOIs block the monoamine enzyme which breaks down noradrenaline, serotonin and some other transmitters. They are Monoamine Oxidase Inhibitors.
Unfortunately, the MAOIs also block an enzyme in the body which breaks down other compounds. One of these is an amino acid called tyramine. Tyramine is an essential compound which the body needs, and is found in many foods. However, if you have too much tyramine in the body, it can make your blood pressure rise. Foods such as cheese, yeast and meat extracts etc contain lots of tyramine. If you eat any of these foods while taking an MAOI, your body can not break down (or metabolise) the tyramine. You then get an excess of tyramine in the body, which increases your blood pressure very quickly. This can at cause headaches initially but can be very dangerous and has caused many deaths.
The MAOIs also affect other transmitters which are broken down by the MAO enzyme.
- Affecting your noradrenaline may also sometimes upset your blood pressure e.g. you may feel dizzy when you stand up etc.

Source.

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Key points about antidepressant therapy

One more thing before I start describing different kinds of antidepressants. Well actually here are 13 things - some key points about antidepressant therapy that can be useful for both those who take their medicine already and those who is about to start. These tips will help you to understand some basics and answer most of the frequently asked questions about antidepressants.

"- It takes from two to six weeks for an antidepressant to begin to work. You may feel worse before you feel better because side effects can occur almost immediately, whereas therapeutic benefits appear later. The good news is that most side effects dissipate within days or weeks.

- Antidepressants are not habit-forming and are not drugs of abuse.

- Do not despair if the first medication does not work. Finding the appropriate medication(s) and dosages may take time. The good news is that many different antidepressants are available.
- The most frequent reason for an antidepressant “failure” is that the dose was too low and the duration of treatment too short.

- Feeling better is not a good reason for discontinuing or reducing your medications. Individuals often are tempted to stop medication too soon, risking relapse or recurrence.

- For individuals with bipolar disorder or recurrent major depression, medication may have to become part of everyday life to avoid return of disabling symptoms.

- You should never mix medications of any kind—prescribed, over-the counter, herbs, or borrowed—without consulting a doctor.

- Some drugs, like alcohol, reduce the effectiveness of antidepressants and should be avoided. This includes wine, beer and hard liquor.

- Some drugs, which are usually safe when taken alone, can cause severe and dangerous side effects if taken with other drugs. Always tell dentists, pharmacists and other medical specialists that you are taking antidepressants.

- If you have been prescribed an MAOI (such as Parnate or Nardil), you will have to avoid certain foods and over-the-counter medications. Be sure to get a complete list of disallowed foods and medications from your doctor and always carry it with you.

- Antianxiety drugs, such as diazepam (Valium) or alprazolam (Xanax), are not antidepressants. They are sometimes prescribed along with antidepressant therapy, but should not be taken alone for a depressive disorder.

- Scientific studies suggest that patients with three or more episodes of depression or two severe episodes may need to be maintained on antidepressants indefinitely. The maintenance dose should be the same as the dose required to achieve an initial therapeutic response.

- Antidepressants work best in most individuals when prescribed alongside a course of psychotherapy. People taking both medication and engaging in psychotherapy generally take less time to feel better and maintain their gains longer than those taking antidepressant medications alone."

Tips are taken from here

Take care!

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Special populations and depression therapy

Today I would like to start speaking about antidepressant therapy as the most common depression cure method. However, before listing different medications in-depth I'll begin with short advices for the below-mentioned groups:

"When deciding on therapy, some clinically depressed patients require special considerations:

Bipolar disorder -- these patients have extreme mood swings (periods of excessive high spirits followed by severe depressive episodes). Typically, the antidepressants are augmented with mood stabilizers.

Children/adolescents -- The SSRI fluoxetine is the only effective (and approved) antidepressant for this age group. There have been reports that children on antidepressants are more likely to commit suicide than those who are not on antidepressants; while some data suggest that this may be true, it has not been proven conclusively. Primary care providers need to weigh the risks of antidepressant therapy versus untreated depression. Most often, treatment carries fewer risks of suicide than non-treatment.

Pregnant/postpartum women -- Depression can be a common symptom during pregnancy and postpartum -- it usually corrects itself, but sometimes severe depression must be treated (in about 10 percent of pregnant/postpartum women). Antidepressants can pass to the fetus and through breast milk. The effects of antidepressants on the developing fetus and newborn are not well known. Therefore, doctors should carefully consider the risks and benefits of treatment.

Treatment for depression is not a short-term process but a long-term project with specific goals of remission and maintenance. Multiple approaches of medication, psychotherapy and patient education are most effective in the treatment of MDD. Close consultation with a physician and/or psychiatrist can provide the best treatment options".

Source

Now good luck and you can now proceed to:

- Noradrenergic and Specific Serotonin Antidepressants (NaSSA)
- Monoamine Oxidase Inhibitors (MAOI)
- Serotonin-Norepinephrine Reuptake Inhibitors (SNRI)
- Tricyclic Antidepressants
- Selective Serotonin Reuptake Inhibitors (SSRI)

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